It is designed to be an integrator of different software systems, and automate business processes (you may have a business process that touches on multiple IT systems - so this solution makes perfect sense - deploy a middleware to manage all the interaction).
Biztalk has/had a bunch of adapters including file adapters, FTP, HTTP, SOAP, SMTP, WCF, MSMQ, MQSeries (now IBM MQ) etc.
It's actually a brilliant product name because it captures the concept of what it does so well.
The replacement for Biztalk is Azure Integration Services.
It is interesting to consider the relationship between "AIS" (as defined above in the Azure context) and "RPA" (or "Robotic Process Automation"). The latter focuses on streamlining human-system interactions, and the former focuses on system-to-system interactions.
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